The site is secure. One common alternative is to give Heartgard for heartworms and intestinal parasites along with Bravecto to prevent fleas and ticks, but there are other choices out there. He had to be put to sleep and Im devastated. We are now at about 45 days since last simparica and he is back to his old self. I sure hope we don't have ongoing problems. I gave 2 of my older Labs a dose of Simparica on a Saturday. In very rare instances, mild side effects and irritations can occur for a short period of time. I took him to the ER they checked his vitals and sent me home. They want another blood draw in 3 weeks to see where she is. Omg Im feeling sick seeing all these bad comments. Gave my 12 year old labradoodle simpatico just before going to my sons for T-Day dinner. $37.98 with Subscribe & Save discount. Hi, we did a spinal tap and MRI, its not viral or bacterial, its called steroid responsive meningitis which essentially is the meninges inflaming on their own, but if you look in this thread youll see others reporting similar symptoms/diagnosis so I do think Simparica trio triggered/caused it. The third ingredient in Simparica Trio is pyrantel. Manufactured by Zoetis, Simparica Trio contains three drugs: sarolaner, moxidectin, and pyrantel pamoate. My poor baby! Nobody knows what causes it or makes one dog recover and another not. I will never give another dose to him! This is just another reason to follow your vet's recommendations for annual physical exams and tests. Shes now in the Er. It is like night and day compared to her regular personality or demeanor. After reading all these reports I am convinced this is the reason our baby is so sick. In isolated cases, however, dogs displayed more serious reactions such as tremors, muscle twitching, and seizures. Does any one think this could be a reaction to Simparico Trio? In addition to the tremors, have you noticed any . Vet thinks it may be Addision disease and wants to test for it. Didnt notice anything with first dose. The .gov means its official.Federal government websites often end in .gov or .mil. I am worried! Your pets condition worsens or does not improve with treatment, You have additional questions or concerns about the use of Simparica or Simparica Trio. Within 24 hours, he would not leave my bedroom, slept all day, no appetite. Why would he knowingly recommend this? The vet did a nasal lavage under anesthesia and got a lot of mucus. This happened the same to my dog.. how si going now with your pet? I gave my black lab mix Simparica for the 1st time on 4/1. Tick titer came back a light positive which lab said was specifically false due to the recent lyme x2 booster i was scared in to giving. The only thing we changed after his checkup if Feb. was his flea and tick treatment. He was given fluids, anti-nausea meds, meds to assist with the inflammation of his esophagus. This morning (12/19/21) was a bit better, still hesitant on the steps but we didnt experience any loss of appetite and was eager to go outside (still some diarrhea though). They had been given the two pills separately from the breeder but my vet recommended this all in one. What scared me and caused me to start doing some more research is while drinking he stops and acts as if he has a lot of peanut butter in his mouth. Gave Simparica to my dog yesterday. Now her dog is very sick and she has to take the dog to the vet every day in the past week. My vet prescribed my 16 week old puppy this drug because of a skin irritation. Thank u Fox I have good news I did get 2 additional in house potassium test done and they both came back normal. I'm using milk thistle and broccoli sprout powder, and going forward I'm going to use HWF Clean Heart for heartworm prevention. My personal dog has had no issues at all, and she's been on it for nearly two years. Bella continues to drink in excess of normal amounts. Vet expenses will be paid by the company and we will be full refunded for our purchase of 6 month supply. gave this to my dog three different times. The company is reimbursing for vet costs. I hope we get to the bottom of it as this is not fun. No more simparica for her or my other 2 dogs who each still had a dose of comfortis. We were told the Neurologist would be between $10,000 to $12,000. Other adverse reactions like lethargy, anorexia, itching, and increased thirst are possible but not very likely. I got my dog Josey up to let him out to pee. Vet office said make sure to give with food. Other alternative drugs are likely to offer poorer protection. It seems to be clearing up with Rx eye drops. I threw him his ball and he actually was interested in it. I can not find any information on a delayed reaction AND my Vet just discredits that its the Simparica because my dog goes to Daycare and could be exposed to other mystery things. for flea and ticks? Today she has fallen 2 or 3 times in the last 8 hours). He's experiencing auto-inmune disease symptoms and we were told he is in critical condition. Final Thoughts on Trifexis vs Simparica. He is fully housebroken and just had a running stool accident in the house. How is your puppy doing? She won't drink E walk or anything The doctor seemed to push this drug on me because the kombi guard was on back order. - she's had several episodes since then. Im convinced it was caused by this drug. I paid $120 for 6 months of poison. I am so incredibly upset with myself for trusting my vet and giving my dog this product. Please anyone let me know if there is a class action law suit or where we can start one? Sunday, he was lethargic and refused to eat. I'm so glad I found this forum, it confirmed my instincts that this drug is very harmful. I gave my 10 year old Bull Terrier a dose of Simparico Trio Thursday December 3. The only change I could think of he started taking Simparica about 4 months ago. Before sharing sensitive information, make sure you're on a federal government site. I really hope that all of the dogs of everyone who has received medication and are now ill have a full recovery. Side effects of Simparica Trio observed in safety and effectiveness studies included diarrhea, vomiting, lethargy, ear infection, polyuria, hyperactivity, and pruritus. Are their enough people to file a class action suit? She looked it up and said they were a ton of recalls and she admitted to me that that is what possibly killed him because it was on the recalls and theyd had mini dogs come in for the same issue. Two days later, she is doing better, but not 100% yet. Now I am terrified for his well being. I keep praying she will recover and I feel so guilty for giving it to her. I sadly started my beautiful dog on Simparica Trio on May 1, 2021. I used to use revolution but they dont cover ticks as well. Consulting vet and will not give Simparica ever again. So bad that the FDA made them put a huge warning now on the package. Many people have reported this as only temporary. Bentlee trusts me an I let him down on this one. How is your dog doing? Does anyone know of anything we can give her to help get this out of her system? Simparica has possibly shown no severe side effects that may concern the health of dogs. Thannks !! He is 5 months old. Simparica Trio should be used with caution in dogs with a history of seizures. Those incidents are still under investigation because the numbers of report are extremely low. I went home and somthing didn't feel right, but I read the leaflet and it said no known side effects. Idk what to do. Did the tremors ever stop? Simparica Trio comes with a customer satisfaction guarantee: Zoetis will cover some or all vet expenses should your dog develop heartworm disease, Lyme disease, a flea infestation, hookworms, or roundworms. I have always used topical tx. The most common side effects of Simparica in dogs are vomiting and diarrhea. She never did that before! Vets have told us repeatedly that it can't be the medication. It sounds as if she's been pinched while sleeping although nothing visible happened. The innovative formula disrupts gamma-aminobutyric acid (GABA) and glutamate receptors, which both play a role in nerve transmissions. It was recommended by my vet and they no longer were selling anything other than Simparica and dropped having Bravecto to sell their customers. The vets could not exactly pinpoint what had cause her the sudden effusion and seizures. Not sure what effects he will continue to have. Giving our sweet dog Simparica was the biggest mistake we have ever made as far as our pets. Unfortunately, I didn't realize the tremors were possibly caused by the drug. I've sent this thread and loads of other information to my vet and zoetis. It started working on him right away, Diarrhea. She will not get this anymore. Always confirm storage temperatures by reading the label. Good appetite and no digestive issues (never had that symptom). He had kidney failure he had seizures he had nervous system problems. Can someone please tell me if their dogs got better after taking the pill? I called the maker of Simparica and filed an FDA case for my dog and told them all of the symptoms she was having from this medicine. He would come out of it when I shook him, so I didn't think anything of it at the time. If undiagnosed he would have died. She started it on 7/22. He already has canine dementia on and off. No appetite, not like Charlie. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. We rushed him to the emergency vet and they put him on keppra to stop the seizures. Will this ever get better as the med wears down? My dog is 9 yrs old . Sarolaner is ingested by fleas and ticks when they bite, and works by over-exciting their nervous system, causing paralysis and death. My dog has had 3 seizures in the past from wearing a flea collar. For the next 3-4 days I noticed he would be a bit hesitant to jump or hop around and play as he normally does (and his appetite was lower than usual). Im a new pet owner and this will sound ignorant Im sure but I had NO IDEA this is how flea meds works and completely trusted my vet who knows my dogs past sensitive history and I was given the drug not even in its package so I could read anything about it but in individual pills. What is a good replacement? She has been taking Trifexis for years with no problem. He will be laying then start shaking all over..Has tremors every 5 minutes for 2 hours now. Made the pressured in to by a vet to give Simparica Trio. I have a vet appointment tomorrow to figure it out. Will not use this again and will warn others. my vet recommended this for both my yorkies. How can it not be the Simparica that did this to my baby when nothing else changed. Monday, Tuesday, Wednesday and Thursday he slept all day, was hesitant to get up, wouldn't play with his ball, continued to drink excessively and shivered. She has been on it for 6 months. She is scared of her own shadow, walks into things at times, trips and stumbles, has become very timid, stares at the wall and has to have either me or my husband in sight at all times. For the first time in 12 years my dog has 6-7 large kidney stones which will require surgery. He is a 6 month old Bloodhound so they are always hyper. It's getting better and I decided to just wait and hope when this stuff clears out in 30 days he goes back to normal. And now that I'm reading all of these comments, a couple of hours ago, my puppy who I thought was sleeping, would be shaking and whining, (I'm used to him having bad dreams, and I'd wake him up from them). Sarolaner is effective against the following tick species: Moxidectin is an antiparasitic drug in the macrocyclic lactone class. First month, the one threw up, same thing second month. We hope this will solve our problems and he can live a healthy and happy life. Over the past month she has stumbled a few times when on walks. I left a lot out but didnt want to make too lengthy post. I was blaming the tremors in his back legs on the fact that he has had both ACLs repaired. It has been five days and the diarrhea started on day 2. I had always thought how can something so lethal to fleas an ticks be safe to ingest? The vet office called simparica hotline to find out if it was safe to give her another one. She's wobbly on her feet and seems lopsided, although her eyes look ok; she is really lethargic and barely lifting her head. I hope there will be a class action lawsuit but most importantly that the word get out to stop this medication from harming another life. I have noticed that recently he seems to stumble a little from time-to-time. Just wanted to share my experience in case anyone else has similar experience with dog's character changing. For: My sincere sympathies to those with horrendous seizure side effects. My personal dog has had no issues at all, and she's been on it for nearly two years. My vet recommended this for my Scooby he justed turned 8 on July 4 and had to take him to vet because of fleas since Monday when he got his first treatment of simparica he's been momping around the house and not eating his food. My sweet, funny, smart as can be baby girl died on 9/26/20. We did skin scrape and they kept saying allergies. . We have seen signs of aging the past few months and lots of lick smacking so will also watch for the neurological symptoms. old . I couldnt figure it out until I googled all the medications the vet has prescribed for her then I came across this forum and I am pissed!! Simparica can cause ataxia, which is the official name for loss of body control. 12/18/21.. he did experience some diarrhea. I just gave Bentlee my Akita Simparica Trio on the 9th. The vet came and picked her up and cut her opened and said and told me she could anything wrong with her so it was either she was poisoned or it was a neurological disorder. But he still is suffering from lethargy, polyuria and polydispia basically still drinks and pees non stop. She spent 4 nights at the University of Auburn emergency room and vet clinic. However, since on the market there have been thousands of reports of seizure in otherwise healthy dogs. Drinking water and peeing excessively. Today started diarrhea & he has gone 5 times so far while not eating much. As I said, the first was a week after taking it, then the 2nd and third seizure happened at day 29. My 9 month old puppy started acting very lethargic after taking simparica trio. We did a cortisone pack to help him manage his "arthritis" symptoms that I totally feel were related to the simparica. Reading your comments, this drug may be the cause. They immediately denied they were in the wrong for prescribing because any meds can have side effects but Im convinced this medication is poison. She is now 2 1/2 months post event. Im just hoping my sweet girl is going to be ok. My English Springer Spaniel(Sadie) received her first dose of Simparica Trio at 12 weeks old, with no noticeable side effects. the vet suggested it because she has hookworm..This morning she was shaking and no appetite..After reading all these comments I am scared to death for her. They have become so bad that she cries and whimpers any time she is laying down. It all depends, sadly. She had some itching and a bit lethargic but is eating very well. I don't want another animal harmed by this stuff, one animal is one to many. Thanks! But now I tell everyone just be aware that this product does have the potential to cause neurological harm. Side effects of Simparica Let us now look at possible side effects when administering Simparica. It is better but not gone. Linda. How is ur puppy? The most common Simparica Trio for dogs side effects are; Lethargy Vomiting Diarrhea Loss of appetite Polydipsia Polyuria Hyperactivity Hyperactivity, polydipsia, and polyuria happened in very rare cases. If you miss a dose of Simparica Trio, give it immediately and resume monthly dosing. How is your dog doing at this time? The Vet's are so busy that even if you can get in you don't get anywhere. https://photos.app.goo.gl/GbP8UmDNBAxJ1m4g8 I feel like we are just waiting for him to pass now. This is so awful. Like many of you, I was unsure about the cause. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. The vet suggested this medication for my 9+ yr old English Bulldog. I shall be looking for a natural product from now on, k and g pet supplies on amazon do a good mange spray so hopefully that will be all they need from now on. Im wondering if anyone else has seen these types of symptoms. Started in February and within a couple of weeks ears started twitching. Hi, Im wondering whats going on with your dog now? I had placed an order with Pet Meds for the prescription before I saw any of these side effects.I will be returning this medication and order Heartgard and not sure what we will do for flea and ticks, since he turns his nos Simparica Trio, e to the Nexgard and we really dont feel safe with our Grandson around the topical or collarAny suggestions? If this was our children and you went to your doctor for a shot, and the Dr. said "don't worry, only 1% of kids get seizures or other problems from this shot, we wouldn't stand for it. and you expect people to give this to their beloved pets? Im wondering if there is any correlation as we havent changed anything else with him. Doubtful our dog will be given Simparica again. Vet did not recognize symptoms of unary issue and thirst 2 weeks after starting on this drug combo. I will post an update 7 days later. She definitely is not herself and behaving strangely. She walks around as if she is on ice with no control of her back legs. Also feed bland diet- rice, ground beef, chicken, cottage cheese. The flea components vary but having had one seizure you're now prone to being sensitive to even the "safer" ones. Then she started having tremors. Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). I gave this to my 8 yr old chihuahua and a couple days later he started having seizures. I check this thread regularly and Im sooo grateful to all who wrote. There is a possibility it isn't the cause, but it is the only reason I can find and it aligns with the stories of others. About 2 weeks later he had tremors, drooling, lethargic, uncoordinated, vomiting and was touch and go for a couple days. The company will not cover any products purchased through sites like Chewy or 1-800-Pet-Meds because they cannot be tracked to ensure they're legitimate and properly stored/handled (and due to the company's stance on product diversion). They are monitoring her. Then the following week 1 pill every other day . I will not be giving this medication again! Today March 20 (8 week old) I get a message saying the puppy ate one of these pills that was for the bigger dog she already owned. Get the dog moms and dads in your life something unique this year. Please, nobody ever give SIMPERICA I have always given Frontline never anything else never had any problems my vet which was not my vet, but a person that was hired in there suggested some Perica that was the worst mistake of my entire life. For 5 years I have resisted my veterinarians suggestions for oral flea meds. My American Akita puppy took this pill on August 8th. Certain age, breed predispositions. I just want to cry! 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